United States is in a desperate search for silver bullet drugs against the rampaging coronavirus which has infected 14,000 and killed an estimated 217 Americans.
U.S. researchers, following the lead of scientists in other countries, have launched studies to see whether widely-available, low-cost generic drugs can be used to help treat the illness caused by the new coronavirus.
There are currently no vaccines or treatments for the highly-contagious COVID-19 respiratory illness, so patients can only receive supportive care for now.
But a 1,500-person trial, led by the University of Minnesota, began this week to see whether malaria treatment hydroxychloroquine can prevent or reduce the severity of COVID-19.
Two other trials are studying the blood pressure drug losartan as a possible treatment for the disease.
The malaria drug, also being tested in China, Australia and France, was touted earlier this week by Tesla Chief Executive Elon Musk, who recovered from malaria in 2000 after taking the medication. And President Trump has wholeheartedly recommended it for use.
Besides having a direct antiviral effect, hydroxychloroquine suppresses the production and release of proteins involved in the inflammatory complications of several viral diseases.
“We are trying to leverage the science to see if we can do something in addition to minimizing contacts,” said Dr. Jakub Tolar, dean of the University of Minnesota Medical School and vice president for clinical affairs. “Results are likely in weeks, not months.”
Most people infected with the new coronavirus develop only mild flu-like symptoms, but around 20 percent can have more severe disease that can lead to pneumonia requiring hospitalization.
The fast-spreading virus, which emerged in China in November/ December 2019 and is now in more than 150 countries, has infected more than 246,000 and killed over 10,000 people worldwide, including at least 217 in the United States. Experts say it could take a year or more to have a preventive vaccine ready, so effective treatments are desperately needed.